• Alejandro Lemor, Mir B Basir, Kirit Patel, Brian Kolski, Amir Kaki, Navin K Kapur, Robert Riley, John Finley, Andrew Goldsweig, Herbert D Aronow, P Matthew Belford, Behnam Tehrani, Alexander G Truesdell, David Lasorda, Aditya Bharadwaj, Ivan Hanson, Thomas LaLonde, Sarah Gorgis, William O'Neill, and National Cardiogenic Shock Initiative Investigators.
• Department of Cardiology, Henry Ford Hospital, Detroit, Michigan. Electronic address: alejandrolemor@outlook.com.
• JACC Cardiovasc Interv. 2020 May 25; 13 (10): 1171-1178.

ObjectivesThis study sought to compare outcomes of patients enrolled in the NCSI (National Cardiogenic Shock Initiative) trial who were treated using a revascularization strategy of percutaneous coronary intervention (PCI) of multivessel PCI (MV-PCI) versus culprit-vessel PCI (CV-PCI).BackgroundIn patients with multivessel disease who present with acute myocardial infarction and cardiogenic shock (AMICS), intervening on the nonculprit vessel is controversial. There are conflicting published reports and lack of evidence, particularly in patients treated with early mechanical circulatory support (MCS).MethodsFrom July 2016 to December 2019, patients who presented with AMICS to 57 participating hospitals were included in this analysis. All patients were treated using a standard shock protocol emphasizing early MCS, revascularization, and invasive hemodynamic monitoring. Patients with multivessel coronary artery disease (MVCAD) were analyzed according to whether CV-PCI or MV-PCI was undertaken during the index procedure.ResultsOf 198 patients with MVCAD, 126 underwent MV-PCI (64%) and 72 underwent CV-PCI (36%). Demographics between the cohorts were similar with respect to age, sex, history of diabetes, prior PCI or coronary artery bypass grafting, and prior history of myocardial infarction. Patients who underwent MV-PCI had a trend toward more severe impairment of cardiac output and worse lactate clearance on presentation, and cardiac performance was significantly worse at 12 h. However, 24 h from PCI, the hemometabolic derangements were similar. Survival and rates of acute kidney injury were not significantly different between groups (69.8% MV-PCI vs. 65.3% CV-PCI; p = 0.51; and 29.9% vs. 34.2%; p = 0.64, respectively).ConclusionsIn patients with MVCAD presenting with AMICS treated with early MCS, revascularization of nonculprit lesions was associated with similar hospital survival and acute kidney injury when compared with culprit-only PCI. Selective nonculprit PCI can be safety performed in AMICS in patients supported with mechanical circulatory support.Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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