• Mackram F Eleid, Allison K Cabalka, Matthew R Williams, Brian K Whisenant, Oluseun O Alli, Neil Fam, Peter M Pollak, Firas Barrow, Joseph F Malouf, Rick A Nishimura, Lyle D Joyce, Joseph A Dearani, and Charanjit S Rihal.
• Department of Cardiovascular Diseases and Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.
• JACC Cardiovasc Interv. 2016 Jun 13; 9 (11): 1161-74.

ObjectivesThis study sought to examine the feasibility, safety, and intermediate-term outcomes in patients undergoing percutaneous transvenous transcatheter mitral valve implantation in failed bioprosthesis, ring annuloplasty, and calcific mitral stenosis.BackgroundSurgical mitral valve replacement in patients with previous surgery or severe mitral annular calcification (MAC) is often associated with high or prohibitive risk.MethodsPercutaneous transfemoral antegrade transseptal implantation of Edwards SAPIEN prosthesis (Edwards Lifesciences, Irvine, California) was performed in 48 patients with degenerated mitral bioprosthesis (n = 33), previous ring annuloplasty (n = 9), and severe MAC (n = 6).ResultsThe mean Society of Thoracic Surgeons risk score was 13.2 ± 7.4% with a mean age 76 ± 11 years. Acute procedural success was achieved in 42 of 48 patients (88%) in the overall group and 31 of 33 (94%) in the failed bioprosthetic mitral valve group and success rate of 11 of 15 (73%) in patients with failed annuloplasty rings and MAC. After successful procedure, no patients had > mild residual mitral prosthetic or periprosthetic regurgitation; mean transvalvular gradients were 6 ± 2.5 mm Hg. Thirty-day survival free of death and cardiovascular surgery was 85% in the overall group and 91% in the failed bioprosthetic mitral valve subgroup.ConclusionsTransfemoral percutaneous transvenous mitral valve implantation in high-risk patients with degenerated bioprosthesis is safe, effective, and associated with rapid improvement in hemodynamics, short length of stays, and improved functional status. Percutaneous mitral valve implantation in patients with failed annuloplasty rings and severe MAC is a promising therapy with significant short-term morbidity and mortality that requires further study.Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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