• Immunity · Jul 2020

    Review

    Cytokine Storms: Understanding COVID-19.

    • Nilam Mangalmurti and Christopher A Hunter.
    • Perelman School of Medicine, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.
    • Immunity. 2020 Jul 14; 53 (1): 19-25.

    AbstractThe elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.Copyright © 2020 Elsevier Inc. All rights reserved.

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