• Elisabeth Coll, Eduardo Miñambres, Ana Sánchez-Fructuoso, Constantino Fondevila, José Luis Campo-Cañaveral de la Cruz, and Beatriz Domínguez-Gil.
• Organización Nacional de Trasplantes, Madrid, Spain.
• Transplantation. 2020 Jan 29.

AbstractUncontrolled Donation after Circulatory Death (uDCD) refers to donation from persons who die following an unexpected and unsuccessfully-resuscitated cardiac arrest. Despite the large potential for uDCD, programs of this kind only exist in a reduced number of countries with a limited activity. Barriers to uDCD are of a logistical and ethical-legal nature, as well as arising from the lack of confidence in the results of transplants from uDCD donors.The procedure needs to be designed to reduce and limit the impact of the prolonged warm ischemia inherent to the uDCD process, and to deal with the ethical issues that this practice poses: termination of advanced cardio-pulmonary resuscitation (aCPR), extension of aCPR beyond futility for organ preservation, family approach to discuss donation opportunities, criteria for the determination of death, or the use of normothermic regional perfusion (NRP) for the in situ preservation of organs.Although the incidence of primary non function and delayed graft function is higher with organs obtained from uDCD donors, overall patient and graft survival is acceptable in kidney, liver and lung transplantation, with a proper selection and management of both donors and recipients. NRP has shown to be critical to achieve optimal outcomes in uDCD kidney and liver transplantation. However, the role of ex situ preservation with machine perfusion is still to be elucidated.uDCD is a unique opportunity to improve patient access to transplantation therapies and to offer more patients the chance to donate organs after death, if this is consistent with their wishes and values.

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