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- Vanessa L Ott, John C Cambier, John Kappler, Philippa Marrack, and Bradley J Swanson.
- Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. ottv@njc.org
- Nat. Immunol. 2003 Oct 1; 4 (10): 974-81.
AbstractStudies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
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