• Joakim Schjølberg Larsen, Eli-Anne Skaug, Ulrik Wisløff, Øyvind Ellingsen, Lars Jacob Stovner, Mattias Linde, and Knut Hagen.
• Department of Neuroscience, Norwegian University of Science and Technology, Norway.
• Cephalalgia. 2016 Dec 1; 36 (14): 1341-1349.

BackgroundReduced endothelial function is associated with elevated risk of cardiovascular disease, but evidence on the association between migraine and endothelial function is conflicting. The aim of this population-based study was to examine the relationship between flow-mediated dilatation (FMD) and migraine with aura, migraine without aura and tension-type headache.MethodsIn the third Nord-Trøndelag Healthy Study (HUNT3) FMD was measured by ultrasound during reactive hyperaemia of the brachial artery in a sample of 4739 healthy adult participants, 3929 of whom answered headache questions. The cross-sectional association between different headache diagnoses and FMD was evaluated by logistic regression, using a categorical approach.ResultsMean FMD did not differ between the headache groups and headache-free controls. In multi-adjusted analyses, no consistent association was found between FMD quintiles and headache groups.ConclusionsThere was no relationship between FMD and migraine or other headache diagnoses in this large cross-sectional study of otherwise healthy respondents including freedom from pulmonary and cardiovascular diseases.© International Headache Society 2016.

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