• Pain management · Nov 2016

    Randomized Controlled Trial

    Flurbiprofen 8.75 mg lozenges for treating sore throat symptoms: a randomized, double-blind, placebo-controlled study.

    • Bernard P Schachtel, Adrian Shephard, Timothy Shea, Kathleen Sanner, Laurie Savino, Jeanne Rezuke, Emily Schachtel, and Sue Aspley.
    • Schachtel Research Company, Inc., Jupiter, FL, USA.
    • Pain Manag. 2016 Nov 1; 6 (6): 519-529.

    AimThis study assessed multiple doses of flurbiprofen 8.75 mg lozenges for the relief of three prominent symptoms of acute pharyngitis: pain intensity (primary end point), difficulty swallowing and swollen throat.Patients & MethodsA total of 204 patients (102 in each group) with confirmed pharyngitis (onset ≤4 days) were randomly assigned to take up to five flurbiprofen or placebo lozenges every 3-6 h, for 7 days. Using validated rating scales (sore throat pain intensity, difficulty swallowing and swollen throat) patients rated their symptoms for the duration of the study.ResultsOver the first 24 h, patients treated with flurbiprofen lozenges reported significantly greater reductions in sore throat pain (47%) as well as difficulty swallowing (66%) and swollen throat (40%) compared with placebo (all p < 0.05).ConclusionMultiple doses of flurbiprofen lozenges provide effective relief of sore throat pain intensity as well as difficulty swallowing and swollen throat.

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