• Ann. Clin. Lab. Sci. · Jan 2003

    Ultrastructural findings in metastatic bronchioloalveolar carcinoma.

    • Mary Aldrene L Tan, Saul Teichberg, Beth Roberts, and Steven I Hajdu.
    • Department of Pathology, North Shore University Hospital, Manhasset, New York, USA.
    • Ann. Clin. Lab. Sci. 2003 Jan 1; 33 (3): 289-94.

    AbstractThis study was prompted by the recent revision of the definition of bronchioloalveolar carcinoma (BAC) that defines BAC, light microscopically, as a non-invasive carcinoma. Doubt has been raised whether BACs retain certain specific microscopic features after becoming invasive or metastatic. We studied 7 cases of metastatic, non-mucinous BAC by electron microscopy. Of these cases, 5 showed Clara cell granules and 1 revealed lamellar bodies. The remaining case did not show ultrastructural features of BAC. These findings suggest that most BACs retain some of their ultrastructural features after becoming metastatic neoplasms.

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