• N. Engl. J. Med. · Sep 2012

    Case Reports

    Use of reprogrammed cells to identify therapy for respiratory papillomatosis.

    • Hang Yuan, Scott Myers, Jingang Wang, Dan Zhou, Jennifer A Woo, Bhaskar Kallakury, Andrew Ju, Michael Bazylewicz, Yvonne M Carter, Christopher Albanese, Nazaneen Grant, Aziza Shad, Anatoly Dritschilo, Xuefeng Liu, and Richard Schlegel.
    • Department of Pathology, Georgetown University Medical Center, Washington, DC 20057, USA.
    • N. Engl. J. Med.. 2012 Sep 27;367(13):1220-7.

    AbstractA patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. The increased size of the latter viral genome was due to duplication of the promoter and oncogene regions. Chemosensitivity testing identified vorinostat as a potential therapeutic agent. At 3 months after treatment initiation, tumor sizes had stabilized, with durable effects at 15 months.

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