• Saleh Nyende, Andrea Conroy, Robert Opika Opoka, Sophie Namasopo, Kevin C Kain, Arthur Mpimbaza, Ravi Bhargava, and Michael Hawkes.
• Department of Paediatrics, Jinja Regional Referral Hospital, Jinja, Uganda. kumbisaleh@gmail.com.
• Trials. 2015 Jul 9; 16: 297.

BackgroundPneumonia is a leading cause of childhood mortality globally. Oxygen therapy improves survival in children with pneumonia, yet its availability remains limited in many resource-constrained settings where most deaths occur. Solar-powered oxygen delivery could be a sustainable method to improve oxygen delivery in remote areas with restricted access to a supply chain of compressed oxygen cylinders and reliable electrical power.Methods/DesignThis study is a randomized controlled trial (RCT). Solar-powered oxygen delivery systems will be compared to a conventional method (oxygen from cylinders) in patients with hypoxemic respiratory illness. Enrollment will occur at two sites in Uganda: Jinja Regional Referral Hospital and Kambuga District Hospital. The primary outcome will be the length of hospital stay. Secondary study endpoints will be mortality, duration of supplemental oxygen therapy (time to wean oxygen), proportion of patients successfully oxygenated, delivery system failure, cost, system maintenance and convenience.DiscussionThe RCT will provide useful data on the feasibility and noninferiority of solar-powered oxygen delivery. This technological innovation uses freely available inputs, the sun and the air, to oxygenate children with pneumonia, and can be applied "off the grid" in remote and/or resource-constrained settings where most pneumonia deaths occur. If proven successful, solar-powered oxygen delivery systems could be scaled up and widely implemented for impact on global child mortality.Trial RegistrationClinicaltrials.gov registration number NCT0210086 (date of registration: 27 March, 2014).

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