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Review Case Reports
Osimertinib for Lung Squamous Cell Carcinoma: A Case Report and Literature Review.
- Yuki Yoshimatsu, Noriyuki Ebi, Ryunosuke Ooi, Takuto Sueyasu, Saori Nishizawa, Miyuki Munechika, Kohei Yoshimine, Yuki Ko, Hiromi Ide, Kosuke Tsuruno, and Kazunori Tobino.
- Department of Respiratory Medicine, Iizuka Hospital, Japan.
- Intern. Med. 2021 Apr 1; 60 (7): 1067-1071.
AbstractThe efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in lung squamous cell carcinoma is said to be low. Thus far, only four cases of osimertinib in lung squamous cell carcinoma have been published. We experienced a case of EGFR mutant lung squamous cell carcinoma in which fifth-line treatment with osimertinib was effective after T790M EGFR mutation turned positive. Osimertinib was resumed after sixth-line chemotherapy was ineffective, showing efficacy again. Osimertinib may be a promising treatment option for EGFR mutant lung squamous cell carcinoma. This is the first report to show its effect in a case of rechallenge after intervening chemotherapy. It may therefore be important to evaluate EGFR in never-smoker lung squamous cell carcinoma patients.
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