• Debbie A Olsson-White, John K Olynyk, Oyekoya T Ayonrinde, Shereen Paramalingam, and Helen I Keen.
• Department of Rheumatology, Fiona Stanley Fremantle Hospital Group, Perth, Western Australia, Australia.
• Intern Med J. 2022 Apr 1; 52 (4): 566-573.

BackgroundUp to 3% of methotrexate (MTX)-treated rheumatoid arthritis (RA) patients might develop liver fibrosis or cirrhosis, requiring effective screening algorithms.AimsTo assess the utility of non-invasive liver fibrosis assessment in RA patients on MTX.MethodsFifty-six patients were recruited from rheumatology outpatient clinics in a public tertiary centre from July 2017 to October 2018. Clinical data was collected. Screening for hepatic fibrosis was performed using transient elastography (TE), aminoaspartate transaminase to platelet ratio index (APRI), Hepascore and Fibrosis-4 index (FIB-4). Those with suspected significant liver fibrosis based on these screening tests were assessed by a hepatologist.ResultsTwenty-seven patients were suspected to have liver fibrosis on screening, including 10/56 (18%) by TE, 20/56 (36%) by Hepascore, 2/56 by APRI (4%) and 1/56 by FIB-4 (2%). Of these 27 patients, 11 were reviewed by a hepatologist and one diagnosed with significant liver fibrosis. TE, but not APRI, Hepascore or FIB-4, was found to have 100% sensitivity and 84% specificity (P = 0.029) for hepatologist-diagnosed liver fibrosis.ConclusionLiver fibrosis develops in a minority of MTX-treated RA patients. The present study suggests that TE is a more sensitive screening test than APRI, FIB-4 or Hepascore in the identification of people with RA at risk of hepatic fibrosis.© 2020 Royal Australasian College of Physicians.

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