• Stereotact Funct Neurosurg · Jan 2013

    Review

    Posttraumatic stress disorder: neurocircuitry and implications for potential deep brain stimulation.

    • Alexander Taghva, Chima Oluigbo, John Corrigan, and Ali R Rezai.
    • Center for Neuromodulation, Department of Neurosurgery, Ohio State University, Columbus, Ohio, USA. alextaghva@gmail.com
    • Stereotact Funct Neurosurg. 2013 Jan 1; 91 (4): 207-19.

    AbstractPosttraumatic stress disorder (PTSD) is a prevalent and highly disabling psychiatric disorder that is notoriously difficult to treat. At some point in their lifetimes, 5-8% of men, 10-14% of women, and up to a quarter of combat veterans carry this diagnosis. Despite pharmacological and behavioral therapies, up to 30% of patients are still symptomatic 10 years after initial diagnosis. Recent advances in imaging have implicated changes in the limbic and autonomic corticostriatopallidothalamocortical (CSPTC) circuitry in the pathogenesis of this disease. Deep brain stimulation modulates CSPTC circuits in movement and other neuropsychiatric disorders. In this review, we discuss the salient clinical features and neurocircuitry of PTSD and propose a neuromodulation strategy for the disorder. Copyright © 2013 S. Karger AG, Basel.

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