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Minerva stomatologica · Sep 2002
Randomized Controlled Trial Comparative Study Clinical TrialBurning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies.
- F Femiano.
- Stomatology Clinic II, University of Medicine and Surgery, Naples, Italy.
- Minerva Stomatol. 2002 Sep 1; 51 (9): 405-9.
BackgroundAlpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS).MethodsWe were interested in extending our studies as to whether alpha-lipoic acid might improve the symptomatology in BMS and therefore carried out a larger open controlled clinical study on the effects of alpha-lipoic acid on BMS symptomatology.ResultsWe have examined the effects on 4 groups of 20 patients with BMS of ALA, compared with bethanecol, Biotene and placebo, and found ALA of remarkable benefit with minimal adverse effects.ConclusionsThese results suggest that double-blind randomized controlled multicenter studies of ALA are indicated.
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