• Internal medicine · Apr 2021

    Two Cases of Autoimmune Neutropenia Complicated with Other Lineages of Autoimmune Cytopenia, Successfully Treated with Prednisolone.

    • Yoshiya Adachi, Yumi Yamazoe-Ishiguri, Satoshi Iwata, Atsushi Murase, Rika Kihara, and Koichi Watamoto.
    • Department of Hematology, Komaki City Hospital, Japan.
    • Intern. Med. 2021 Apr 15; 60 (8): 1271-1277.

    AbstractThough adult-onset primary autoimmune pancytopenia (AIP) rarely follows a self-limited course, a standard treatment strategy has not yet been established. We herein report two cases, each involving primary autoimmune neutropenia complicated with autoimmune thrombocytopenia or Evans syndrome. They were refractory to granulocyte-colony stimulating factor, but all lineages of cytopenia promptly recovered with prednisolone (PSL). In case 1, PSL was tapered and discontinued six months after its initiation without AIP relapse. In case 2, PSL has been tapered for five months without relapse. To establish an optimal treatment strategy for AIP, it is necessary to accumulate more cases.

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