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- Eleanor Jones, Udayaraj Umasankar, Habeeba Mallu, Timothy Hampton, Angela Kulendran, and Mehool Patel.
- University Hospital Lewisham, Lewisham, UK.
- Clin Med (Lond). 2020 Nov 1; 20 (6): 600602600-602.
AbstractOxycodone-induced leukoencephalopathy is a rare diagnosis that should be considered in unconscious patients with appropriate history. We describe a case of a 57-year-old unconscious woman who required intubation and did not respond to naloxone infusion. The unconsciousness was initially thought to be due to hypoxic brain injury. However, a further review of brain imaging showed characteristic features of oxycodone-induced leukoencephalopathy. We describe the pathological and radiological features of this condition, and provide a concise review of the limited literature on this condition. Accurate diagnosis of this condition will be valuable to clinicians and patients in terms of their medium-term and long-term prognosis, and potential for rehabilitation.© Royal College of Physicians 2020. All rights reserved.
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