• Jacqueline L Bender, Arun Radhakrishnan, Caroline Diorio, Marina Englesakis, and Alejandro R Jadad.
• Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Toronto, Canada Department of Health Policy, Management and Evaluation, Faculty of Medicine, University of Toronto, Toronto, Canada Department of Family and Community Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada Faculty of Medicine, University of Toronto, Toronto, Canada University Health Network, Toronto, Canada Centre for Global eHealth Innovation, University of Toronto and University Health Network, Toronto, Canada.
• Pain. 2011 Aug 1; 152 (8): 1740-1750.

AbstractGiven the increasing penetration and health care related use of the Internet, we examined the evidence on the impact of Internet-based interventions on pain. A search of Medline, CINAHL, PsycINFO, and the Cochrane Library was conducted for literature published from 1990 to 2010 describing randomized controlled trials that assessed the effects of Internet-based interventions on patients with pain of any kind. Of 6724 citations, 17 articles were included. The studies evaluated the effects of interventions that provided cognitive and behavioral therapy, moderated peer support programs, or clinical visit preparation or follow-up support on 2503 people in pain. Six studies (35.3%) received scores associated with high quality. Most cognitive and behavioral therapy studies showed an improvement in pain (n=7, 77.8%), activity limitation (n=4, 57.1%) and costs associated with treatment (n=3, 100%), whereas effects on depression (n=2, 28.6%) and anxiety (n=2, 50%) were less consistent. There was limited (n=2 from same research group) but promising evidence that Internet-based peer support programs can lead to improvements in pain intensity, activity limitation, health distress and self-efficacy; limited (n=4 from same research group) but promising evidence that social networking programs can reduce pain in children and adolescents; and insufficient evidence on Internet-based clinical support interventions. Internet-based interventions seem promising for people in pain, but it is still unknown what types of patients benefit most. More well-designed studies with diverse patient groups, active control conditions, and a better description of withdrawals are needed to strengthen the evidence concerning the impact of Internet-based interventions on people in pain.Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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