• Med. Clin. North Am. · Jan 2021

    Review

    Approach to Fatigue: Best Practice.

    • Jason C Dukes, Matthew Chakan, Aaron Mills, and Maurice Marcaurd.
    • Internal Medicine Department, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 565, Norfolk, VA 23507, USA. Electronic address: dukesjc@evms.edu.
    • Med. Clin. North Am. 2021 Jan 1; 105 (1): 137-148.

    AbstractOwing to the broad differential diagnoses that can present as fatigue, a rational approach to diagnosis is paramount. Performance of a battery of diagnostic tests is unlikely to assist with diagnosis, highlighting the importance of a thorough history and physical examination. Fatigue can be a sequela of an underlying medical disease or exists as a primary condition. Management of secondary fatigue largely depends on treatment of the underlying condition. There are no FDA-approved medications for primary fatigue, now known as system exertion intolerance disease. Treatment is focused on individualized exercise therapy and cognitive behavioral therapy.Copyright © 2020 Elsevier Inc. All rights reserved.

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