• Tetsuya Nemoto, Satoshi Ito, Daisuke Kobayashi, Chinatsu Takai, Syunsuke Sakai, Youichi Kurosawa, Eriko Hasegawa, Ryo Okabayashi, Asami Abe, Hiroshi Otani, Hyunho Lee, Akira Murasawa, Ichiei Narita, Kiyoshi Nakazono, ToyoshimaYoichiDepartment of Rheumatology, Niigata Rheumatic Center, Japan.Department of Orthopedic Surgery, Showa University School of Medicine, Japan., Katunori Inagaki, and Hajime Ishikawa.
• Department of Rheumatology, Niigata Rheumatic Center, Japan.
• Intern. Med. 2021 May 1; 60 (9): 1359-1367.

AbstractObjective To evaluate the effectiveness and drug retention rate of golimumab (GLM) for long-term use in daily practice for patients with rheumatoid arthritis (RA). Methods Patients with RA who started GLM therapy with a minimum follow-up period of 52 weeks were included. The patients were divided into a biologic-naïve group and switch group. The disease activity score (DAS) 28-erythrocyte sedimentation rate (ESR) (DAS28-ESR), grip power, and Japanese version of the health assessment questionnaire (J-HAQ) score were assessed. In addition, the treatment continuation rate was evaluated at the final follow-up. Patients Sixty-five patients [58 women and 7 men; median (range) age, 69 (61-74) years; median (range) disease duration, 9 (5-16) years] were included. Twenty-eight patients were biologic-naïve (naïve group), and 37 were switched to biologics (switch group). Results The median (range) follow-up period was 134 (58-162) weeks. The DAS28-ESR improved from a median (range) of 4.31 (3.52-5.25) to 2.65 (2.28-3.77) in the naïve group and from 4.27 (3.19-4.89) to 2.89 (2.49-3.88) in the switch group. The grip power improved in both groups (p<0.01); however, the J-HAQ score showed no marked improvement in either group. The continuation rates were 22/28 (78.6%) in the naïve group, and 26/37 (70.3%) in the switch group at the final follow-up. Conclusion We herein report for the first time that the long-term use of GLM improves the grip power. Improving the grip power may help prevent sarcopenia and frailty in the future. Given the efficacy and high continuation rate, we suggest that GLM would be a well-tolerated treatment option for RA.

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