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- Francesco Lacarrubba, Maria Rita Nasca, Davide Francesco Puglisi, and Giuseppe Micali.
- Dermatology Clinic, University of Catania, Italy.
- Int. J. Clin. Pract. 2020 Dec 1; 74 Suppl 187: e13626.
AbstractUrea is a hygroscopic molecule that, because of its moisturising properties, is topically used for the treatment of skin dryness at concentrations ranging from 2% to 12% in different formulations. Based on existing literature, low-concentration urea-containing products are effective in the treatment and/or prevention of xerosis in some skin disorders such as ichthyosis, atopic dermatitis and psoriasis, or unrelated to specific skin diseases. Generally, urea formulations at low concentration are well-tolerated and suited for the treatment of large skin areas, once or twice daily, even for a long period of time. At low concentrations stinging and burning sensation is rare and transient, whit no reported sensitisation despite its widespread use.© 2020 John Wiley & Sons Ltd.
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