• Int. J. Clin. Pract. · Dec 2020

    Clinical evidences of urea at medium concentration.

    • Federica Dall'Oglio, Aurora Tedeschi, Anna Elisa Verzì, Francesco Lacarrubba, and Giuseppe Micali.
    • Dermatology Clinic, University of Catania, Catania, Italy.
    • Int. J. Clin. Pract. 2020 Dec 1; 74 Suppl 187: e13815.

    AbstractUrea-based topical compounds at medium concentrations (15%-30%) represent useful dermatological agents for their humectant and keratolytic effects by enhancing stratum corneum hydration and by loosening epidermal keratin, respectively. The aim of this paper is to review the clinical evidences of the use of 15%-30% urea as single topical agent. Although limited evidence supports the use of these concentrations of urea in skin disorders characterised by xerosis and hyperkeratosis, in clinical practice they are largely used especially in xerosis of limited skin areas, in which the side effects are tolerable, or hyperkeratosis involving large or more sensitive (eg, face, genital region, etc) areas, in which higher concentration may be irritant. In addition, urea at medium concentrations is used in combination with other substances including topical antifungals as penetration enhancer.© 2020 John Wiley & Sons Ltd.

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