• Helene K Nedergaard, Hanne Irene Jensen, Hanne Tanghus Olsen, Thomas Strøm, Jørgen T Lauridsen, Gisela Sjøgaard, and Palle Toft.
• Department of Anesthesiology and Intensive Care, Lillebaelt Hospital, University Hospital of Southern Denmark, Kolding, Sygehusvej 24, 6000 Kolding, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsløwsvej 19, 5000 Odense, Denmark. Electronic address: helene.korvenius.nedergaard@rsyd.dk.
• J Crit Care. 2021 Apr 1; 62: 58-64.

PurposeCritical illness impairs physical function. The NONSEDA trial was a multicenter randomized trial, assessing non-sedation versus sedation during mechanical ventilation. The aim of this sub-study was to assess the effect of non-sedation on physical function.MethodsAll patients from one NONSEDA trial site were included. At ICU discharge and three months thereafter, survivors were assessed for physical function.Results205 patients were included, 118 survived to follow-up, 116 participated (98%).Primary OutcomeThree months after ICU-discharge, health-related quality of life (SF-36, physical component score) was similar (non-sedated 38.3 vs sedated 36.6, mean difference 1.7, 95% CI -1.7 to 5.1), as was function in activities of daily living (Barthel Index, non-sedated 19.5 vs sedated 18, median difference 1.5, 95% CI -0.2 to 3.2).Secondary OutcomesNon-sedated patients had a better Barthel Index at ICU-discharge (median 9 vs 4, median difference 5, 95% CI 2.5 to 7.5). At three months post-ICU discharge, the two groups did not differ regarding handgrip strength, walking distance, muscle size or biomechanical data.ConclusionNon-sedation did not lead to improved quality of life regarding physical function or better function in activities of everyday living. Non-sedated patients had a better physical recovery at ICU discharge.Trial RegistrationClinicaltrials.govNCT02034942, registered January 14., 2014.Copyright © 2020. Published by Elsevier Inc.

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