• Br J Anaesth · Nov 1988

    Randomized Controlled Trial Clinical Trial

    Changes in pupil diameter after oral administration of codeine.

    • J E Peacock, P D Henderson, and W S Nimmo.
    • University Department of Anaesthesia, University of Sheffield Medical School.
    • Br J Anaesth. 1988 Nov 1; 61 (5): 598-600.

    AbstractPupillary constriction occurs following administration of opioids and may be used as a marker of opioid activity. We have measured plasma concentrations and pupil diameters in 16 healthy volunteers after the oral administration of placebo or codeine. Pupil size decreased significantly after codeine compared with placebo. Pupil size was related to the plasma concentrations of codeine (P less than 0.05).

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