• Eurosurveillance · Jun 2020

    Meta Analysis

    Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications.

    • Saverio Caini, Federica Bellerba, Federica Corso, Angélica Díaz-Basabe, Gioacchino Natoli, John Paget, Federica Facciotti, Simone Pietro De Angelis, Sara Raimondi, Domenico Palli, Luca Mazzarella, Pier Giuseppe Pelicci, Paolo Vineis, and Sara Gandini.
    • Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
    • Eurosurveillance. 2020 Jun 1; 25 (23).

    AbstractWe reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.

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