• Internal medicine · May 2021

    Case Reports

    Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies.

    • Shinichi Wada, Mayu Kamei, Naoko Uehara, Koji Tsuzaki, and Toshiaki Hamano.
    • Department of Neurology, Kansai Electric Power Hospital, Japan.
    • Intern. Med. 2021 May 15; 60 (10): 1607-1610.

    AbstractA 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX-1 antibodies. He was diagnosed with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS). He died from aspiration pneumonia on day 9. Small-cell lung carcinoma (SCLC), which had not been obvious on computed tomography, was found during the autopsy. Patients with PCD-LEMS who test positive for SOX-1 antibodies should be carefully evaluated for SCLC.

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