• Leon A Simons, Michael Ortiz, and Gordon Calcino.
• St Vincent's Hospital, University of New South Wales, Sydney, NSW, Australia. l.simons@unsw.edu.au
• Med. J. Aust. 2011 Aug 1; 195 (3): 134-7.

ObjectiveTo study patient persistence on therapy for hypertension and dyslipidaemia using a single-pill combination compared with a two-pill approach.Design And SettingPost-hoc observational assessment of Pharmaceutical Benefits Scheme claim records covering the period April 2005 to March 2010.ParticipantsA 10% random sample of Australian long-term concession card holders was analysed. The patients studied had commenced on either amlodipine and atorvastatin as two individual pills, or a single pill containing both amlodipine and atorvastatin (AA), with neither combined approach having been dispensed to them in the previous 6 months.Main Outcome MeasuresThe proportions of patients failing to fill their first repeat prescription after 1 month or failing to persist with treatment at 12 months, and the median persistence time (MPT) were measured.ResultsOf 4146 patients prescribed the AA single pill, 11% failed to fill the first repeat prescription and 33% had ceased treatment by 12 months (MPT, 35 months). Of 6204 patients prescribed amlodipine and atorvastatin as two pills, 23% failed to fill the first repeat prescriptions and 59% had ceased treatment by 12 months (MPT, 7 months). In a multivariate model, cessation of single-pill therapy increased by 165% if there was no prior therapy, but only increased by 48%-55% if there was no prior therapy with a calcium channel blocker or statin. MPT on the single pill was 8 months in those without prior antihypertensive therapy, but was ≥ 37 months in those with any prior antihypertensive therapy.ConclusionA single-pill combination drug is associated with superior long-term persistence compared with two-pill therapy in the management of hypertension and dyslipidaemia.

21 keywords...

hide…