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Case Reports
Utility of Basophil Activation Test in a Case of Daisaikoto- and Yokukansan-induced Lung Injury.
- Tomoko Kawahara, Munehiro Yamaguchi, Chisato Onitsuka, Tomoyuki Kimura, Tetsuya Homma, and Hironori Sagara.
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan.
- Intern. Med. 2021 May 15; 60 (10): 157315761573-1576.
AbstractDrug-induced lung injury is defined as a respiratory disorder. The usefulness of the basophil activation test (BAT) for drug allergy-related cases was recently reported. The patient was an 82-year-old woman who had been taking Daisaikoto and Yokukansan (herbal medicines) 3 months before developing dry cough. She was admitted to our hospital with an initial diagnosis of pneumonia with elevated serum LDH, KL-6, and IgE. Chest CT showed bilateral ground-glass opacities. Her bronchoalveolar lavage fluid showed increased eosinophils. Finally, a BAT was positive for both medications. Based on the findings, the patient was diagnosed with Daisaikoto- and Yokukansan-induced lung injury. The current case suggests that the BAT may be useful for the diagnosis of drug-induced lung injury.
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