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J. Thromb. Haemost. · Jun 2018
Comparative StudyReversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor.
- A Bertling, A C Fender, L Schüngel, M Rumpf, K Mergemeier, G Geißler, W Sibrowski, R Kelsch, J Waltenberger, J A Jakubowski, and B E Kehrel.
- Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany.
- J. Thromb. Haemost. 2018 Jun 1; 16 (6): 1089-1098.
AbstractEssentials Successful outcome of platelet transfusion depends on specific antiplatelet therapy in use. We assessed if ticagrelor, clopidogrel or prasugrel impacts on donor platelet activity ex vivo. Ticagrelor and/or its active metabolite in plasma or bound to platelets can inhibit donor platelets. This might compromise the effectiveness of platelet transfusion therapy.© 2018 International Society on Thrombosis and Haemostasis.
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