• Curr Vasc Pharmacol · Jan 2018

    Review

    What is the Role of Cangrelor in Patients Undergoing PCI?

    • Michal Droppa and Tobias Geisler.
    • Department of Cardiology and Cardiovascular Medicine, University Hospital of Tubingen, Tubingen, Germany.
    • Curr Vasc Pharmacol. 2018 Jan 1; 16 (5): 484-489.

    AbstractDual antiplatelet therapy with aspirin and oral P2Y12-receptor inhibitors prevents ischemic events in patients undergoing Percutaneous Coronary Intervention (PCI). However, oral administration of antiplatelet drugs cause delay of onset of platelet inhibition in P2Y12-inhibitor naïve patients. Cangrelor is a novel P2Y12-receptor inhibitor which is administrated intravenously and thus allows immediate antiplatelet inhibition during PCI. Due to its unique pharmacokinetics with fast onset of platelet inhibition and very short plasma half-life it allows effective and controllable periprocedural platelet inhibition. It could reduce short-term ischemic events in large randomized clinical trials. The present article reviews the available evidence and application on cangrelor use in clinical practice.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

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