• Intern Emerg Med · Aug 2021

    Letter

    Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis.

    • Ludovico Luca Sicignano, Maria Grazia Massaro, Marinica Savino, Donato Rigante, Laura Gerardino, and Raffaele Manna.
    • Institute of Internal Medicine, Periodic Fever and Rare Diseases Research Centre, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
    • Intern Emerg Med. 2021 Aug 1; 16 (5): 1391-1394.

    AbstractThe clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.© 2021. The Author(s).

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