• Sarah Gietl, Carmen M Schönegger, Markus Falk, Stefanie Weiler, Simone Obererlacher, Bianca Jansen, Sissy-Therese Sonnleitner, and Gernot Walder.
• Dr Gernot Walder Medical Laboratory, Außervillgraten, Austria sarahgietl@gmail.com.
• Clin Med (Lond). 2021 Jan 1; 21 (1): e9e13e9-e13.

AbstractA cohort of the first 50 COVID-19 patients in East Tyrol, a region in the southwest of Austria, were monitored in home quarantine. Specific viral ribonucleic acid was detected in throat swabs and stool samples. Analysis indicated a median virus shedding duration of 13 days; however, statistical outliers highlight the importance of consequent testing. This underlines the need of negative throat swabs prior to removing quarantine. We monitored the disease's characteristics via an in-house score called Corona Severity Index, in order to predict an aggravation of the disease. Special attention was paid to early symptoms, such as headache, which appeared to be significantly more common in younger patients (p=0.019). Anosmia and ageusia showed a predominance in female patients (p=0.028). Investigation revealed seven relapses and viral shedding fluctuation in four cases. A follow-up examination shed light on seroconversion which could be observed in 35 of 40 participants. This further clarifies the necessity of establishing discharge standards and follow-up management for COVID-19 patients.© Royal College of Physicians 2021. All rights reserved.

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