• Duodecim · Jan 2012

    Review

    [New insights in the pathogenesis and treatment of rosacea].

    • Riitta Palatsi, Hanna-Leena Kelhälä, and Päivi Hägg.
    • OYS, ihotautien klinikka.
    • Duodecim. 2012 Jan 1; 128 (22): 2327-35.

    AbstractThe production of cathelicidin, an antimicrobial peptide is strongly increased in rosacea. Cathelicidin activates innate immunity, inflammation and angiogenesis. Cutaneous proteases produce inflammatory fragments of cathelicidin. UV-B irradiation and microbial components increase vitamin D3 and TLR2 expression in keratinocytes leading to an increase of cathelicidin production. Retinoids and doxycycline inhibit inflammation, proteases, angiogenesis and TLR2 expression. A multicenter study 2010 proved that isotretinoin with a dose of 0,3 mg/kg/d for 12 weeks and doxycycline with the dose of 100 mg/d for 14 days followed with 50 mg/d were equally effective. Doxycycline 40 mg/d is also effective in milder cases.

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