• Carrie J Nobles, Pauline Mendola, Sunni L Mumford, Ashley I Naimi, Edwina H Yeung, Keewan Kim, Hyojun Park, Brian Wilcox, Robert M Silver, Neil J Perkins, Lindsey Sjaarda, and Enrique F Schisterman.
• From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (C.J.N., P.M., S.L.M., E.H.Y., K.K., H.P., N.J.P., L.S., E.F.S.); Graduate School of Public Health, University of Pittsburgh, PA (A.I.N.); Department of Obstetrics and Gynecology, Geisinger Commonwealth School of Medicine, Scranton, PA (B.W.); and Department of Obstetrics and Gynecology, School of Medicine, Salt Lake City, University of Utah (R.M.S.).
• Hypertension. 2018 May 1; 71 (5): 904-910.

AbstractElevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007-2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss. Systolic and diastolic blood pressure were measured during preconception in the first observed menstrual cycle and in early pregnancy and used to derive mean arterial pressure. Fecundability was assessed as number of menstrual cycles until pregnancy, determined through human chorionic gonadotropin testing. Pregnancy loss included both human chorionic gonadotropin-detected and clinical losses. Analyses adjusted for treatment assignment, age, body mass index, race, marital status, smoking, parity, and time since last loss. Mean preconception systolic and diastolic blood pressure were 111.6 mm Hg (SD, 12.1) and 72.5 (SD, 9.4) mm Hg. Risk of pregnancy loss increased 18% per 10 mm Hg increase in diastolic blood pressure (95% confidence interval, 1.03-1.36) and 17% per 10 mm Hg increase in mean arterial pressure (95% confidence interval, 1.02-1.35) in adjusted analyses. Findings were similar for early pregnancy blood pressure. Preconception blood pressure was not related to fecundability or live birth in adjusted analyses. Findings suggest that preconception blood pressure among healthy women is associated with pregnancy loss, and lifestyle interventions targeting blood pressure among young women may favorably impact reproductive health.© 2018 American Heart Association, Inc.

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