• Pathogens · Nov 2020

    Case Reports

    COVID-19 as a Trigger of Recurrent Guillain-Barré Syndrome.

    • Erin P McDonnell, Nicole J Altomare, Yesha H Parekh, Ram C Gowda, Payal D Parikh, Mark H Lazar, and Martin J Blaser.
    • Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
    • Pathogens. 2020 Nov 19; 9 (11).

    AbstractCoronavirus 2019 (COVID-19) has been reported to trigger Guillain-Barré syndrome (GBS). While uncommon, recurrent GBS (rGBS) episodes, triggered by antecedent viral infections, have been reported in a small proportion of GBS patients, here we describe a patient with a recurrent case of GBS, occurring secondary to COVID-19 infection. Before this patient's episode, he had two prior GBS flares, each precipitated by a viral infection followed by complete recovery besides intermittent paresthesias. We also consider the nosology of this illness in the spectrum of rGBS and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), with their differing natural histories, prognosis, and therapeutic approaches. For patients who have a history of inflammatory demyelinating polyradiculopathies who develop COVID-19, we recommend close observation for neurologic symptoms over the next days and weeks.

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