• Int J Pharm Compd · Nov 2019

    Basics: Excipients Used in Nonsterile Compounding, Part 3: Preservatives.

    • Loyd V Allen.
    • International Journal of Pharmaceutical Compounding. lallen@ijpc.com.
    • Int J Pharm Compd. 2019 Nov 1; 23 (6): 472-477.

    AbstractPreservative selection is a critical step in the preparation of a formulation to ensure its microbiological effectiveness and stability. A number of physicochemical factors must be considered when selecting a preservative, including concentration, solubility, and pH. A preservative must also be nontoxic, stable, compatible, inexpensive, and have an acceptable taste, odor, and color. It should also be effective against a wide variety of bacteria, fungi, and yeasts, and be free from incompatibilities. This article discusses some of the factors involved in selecting an appropriate preservative.Copyright© by International Journal of Pharmaceutical Compounding, Inc.

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