• Cleve Clin J Med · Feb 2021

    Reversal of direct oral anticoagulants: Highlights from the Anticoagulation Forum guideline.

    • Haeshik S Gorr, Lucy Yun Lu, and Eric Hung.
    • Department of Medicine, Hennepin Healthcare; Assistant Professor of Medicine, University of Minnesota Medical School, Minneapolis, MN Haeshik.gorr@hcmed.org.
    • Cleve Clin J Med. 2021 Feb 1; 88 (2): 98-103.

    AbstractThe 2019 guideline from the Anticoagulation Forum provides clear instructions on how to use 2 agents for reversing the effects of direct oral anticoagulants (DOACs): idarucizumab for dabigatran-associated bleeding and andexanet alfa for bleeding associated with rivaroxaban and apixaban. The guideline also discusses off-label use of andexanet alfa for bleeding associated with edoxaban and betrixaban and the use of hemostatic agents such as activated prothrombin complex concentrate and 4-factor prothrombin complex concentrate. Lastly, it offers approaches for building and managing stewardship programs at the health system level.Copyright © 2021 The Cleveland Clinic Foundation. All Rights Reserved.

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