• Medicine · Jan 2021

    Meta Analysis Observational Study

    Prognostic value of lymphocyte-to-monocyte ratio previously determined to surgery in patients with non-metastatic renal cell carcinoma: A systematic review and a prisma-compliant meta-analysis.

    • Dario Garcia-Rojo, Angel Prera, Jesus Muñoz-Rodriguez, Joan Carles Oliva, Arturo Dominguez, and Joan Prats.
    • Urology Department.
    • Medicine (Baltimore). 2021 Jan 22; 100 (3): e24152e24152.

    BackgroundThe prognostic value of pretreatment lymphocyte to monocyte ratio in patients with renal cell carcinoma and, especially, in non-metastatic patients remains controversial.MethodsWe conducted a PRISMA-compliant meta-analysis to systematically assess the prognostic value of LMR in patients with non-metastatic RCC. Overall survival, cancer-specific survival, and disease-free survival were analyzed. Pooled hazard ratios and 95% confidence intervals were calculated.ResultsSeven studies comprising 4666 patients were included in the analysis. Unlike those observed in a previous meta-analysis, a lower lymphocyte to monocyte ratio was associated with poorer cancer-specific survival (fix-effect model, hazard ratio 3.04, 95% confidence intervals 2.05-4.51, P < .05). Heterogeneity Chi-squared value Q exp = 0. (P = .82) (I2 = 0%). However, the association between a low lymphocyte to monocyte ratio and overall survival or disease-free survival did not obtain significance.ConclusionA lower lymphocyte to monocyte ratio implied poor cancer-specific survival in patients with non-metastatic renal cell carcinoma. Prospective studies are required to confirm our findings.Registration NumberClinicalTrials.gov (identifier: NCT04213664).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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