• Hiroki Hosoi, Toshiki Mushino, Kazutaka Nakashima, Kodai Kuriyama, Shinobu Tamura, Shogo Murata, Ken-Ichi Imadome, Koichi Ohshima, and Takashi Sonoki.
• Department of Hematology/Oncology, Wakayama Medical University, Japan.
• Intern. Med. 2021 Jul 1; 60 (13): 2119-2123.

AbstractA 30-year-old woman was diagnosed with T-lymphoblastic lymphoma (T-LBL) that harbored a clonal Epstein-Barr virus (EBV) genome. At relapse, axillary lymph node adenopathy, which was diagnosed as peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was detected. Southern blot analyses of the T-cell receptor and EBV genome revealed that the T-LBL and PTCL-NOS were clonally identical. We previously showed that CD21 acted as an entry molecule that allowed EBV into the patient's T-LBL cells. Interestingly, the PTCL-NOS cells lacked CD21 expression. Our case suggests that EBV might infect immature CD21-positive T-cells, and CD21-negative PTCL-NOS might subsequently arise through phenotypic changes.

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