• Tiina M Andersen, Brit Hov, Thomas Halvorsen, Ola Drange Røksund, and Maria Vollsæter.
• Thoracic Department, Norwegian Advisory Unit on Home Mechanical Ventilation, Haukeland University Hospital, Bergen, Norway. tiina.andersen@helse-bergen.no.
• Respir Care. 2021 Jul 1; 66 (7): 119612131196-1213.

AbstractWhen the ability to cough is impaired, secretion clearance may be assisted and augmented with mechanical insufflation-exsufflation (MI-E). In some individuals, the efficacy of MI-E may be hampered by counterproductive upper airway reactions, where the airways close in response to positive pressures. To fully utilize the therapeutic potential inherent in the MI-E technology, we need a better understanding of the pathophysiology behind these untoward reactions. There is increasing interest in monitoring and measuring upper airway responses to MI-E and how such information can be used to optimize MI-E settings. The purpose of this narrative review is to increase the theoretical understanding of the larynx as a respiratory organ, summarize the current literature in the area, and provide insight into how this knowledge can affect current clinical practice.Copyright © 2021 by Daedalus Enterprises.

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