• Internal medicine · Jul 2021

    Case Reports

    Refractory Duodenal Bleeding Ulcers Successfully Treated with Factor XIII Transfusion.

    • Yusuke Yamada, Tomohiro Abe, Hidenobu Ochiai, and Shinya Ashizuka.
    • Department of Trauma and Critical Care Medicine, University of Miyazaki Hospital, Japan.
    • Intern. Med. 2021 Jul 15; 60 (14): 2217-2221.

    AbstractA 67-year-old woman with a history of autoimmune hepatitis was admitted for fever, acute hepatic dysfunction, and acute kidney injury. She was diagnosed with multiple duodenal ulcers. Despite the administration of proton pump inhibitor and red blood cells, her black stool and anemia progressed, and she was therefore transferred to our hospital. Despite hemostatic treatments, she continued to bleed. On the 21st day of admission, an endoscopic examination showed the oozing of blood from the duodenal mucosa. A low factor XIII (FXIII) activity level was detected, and she was administered FXIII concentrate. The bleeding stopped and she was thereafter discharged.

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