• Internal medicine · Aug 2021

    Case Reports

    Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus.

    • Keiichiro Kadoba, Keisuke Nishimura, Kaori Uchino, Daisuke Waki, Hiroyuki Murabe, and Toshihiko Yokota.
    • Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Japan.
    • Intern. Med. 2021 Aug 1; 60 (15): 2495-2497.

    AbstractAge-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.

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