• Internal medicine · Jan 2021

    Case Reports

    Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis.

    • Ryotaro Sakamori, Ryoko Yamada, Kazuma Shinkai, Akira Doi, Yuki Tahata, Minoru Shigekawa, Takahiro Kodama, Hayato Hikita, Tomomi Yamada, Tomohide Tatsumi, and Tetsuo Takehara.
    • Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan.
    • Intern. Med. 2021 Jan 1; 60 (5): 745-750.

    AbstractHepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologic response (SVR) in patients with decompensated liver cirrhosis have not been reported. We present the first report of skeletal muscle mass improvement with the achievement of SVR for HCV in a 76-year-old woman with decompensated liver cirrhosis. After achieving SVR through ledipasvir/sofosbuvir treatment, the patient showed an improvement in her liver function and an increase in her skeletal muscle mass.

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