• X H Zhu, J X Li, and F Wang.
• Emergenyc Deartment, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
• Hunan Yi Ke Da Xue Xue Bao. 2000 Dec 28; 25 (6): 576-8.

ObjectiveTo evaluate the efficacy of the native flumazenil for acute self-poisoning with benzodiazepines.MethodsOne hundred and twenty-six patients with unconsciousness from benzodiazepines-induced self-poisoning were randomly divided into two groups: flumazenil group(Group II, 63 cases) were treated with flumazenil, and conventional-medicine group(Group I, 63 cases) with placebo(glucose, vitamin C, KCl). A modified Glasgow Coma Scale(MGCS) and Observer's Assessment of Alertness/Sedation Scale(OAA/S) were used in the assessment of consciousness.ResultsMGCS were increased by 5.3, 8.0, 9.4 and 7.3 at 15 min, 30 min, 60 min and 180 min after intravenous flumazenil(P < 0.01) and by 5.2, 7.7, 8.7 and 6.9 in comparison with conventional-medicine group(P < 0.01). OAA/S increased by 1.9 compared with conventional-medicine group(P < 0.01). No severe side-effects were found in the treatment.ConclusionsFlumazenil might improve benzodiazepines-induced unconsciousness markedly and may be the most effective antagonist of benzodiazepines.

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