• Jan Mehrholz, Simone Mückel, Frank Oehmichen, and Marcus Pohl.
• Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany Department of Public Health, Medizinische Fakultät 'Carl Gustav Carus', Technische Universität Dresden, Dresden, Germany.
• BMJ Open. 2015 Dec 23; 5 (12): e008828.

ObjectivesTo describe the time course of recovery of walking function and other activities of daily living in patients with intensive care unit (ICU)-acquired muscle weakness.DesignThis is a cohort study.ParticipantsWe included critically ill patients with ICU-acquired muscle weakness.SettingPost-acute ICU and rehabilitation units in Germany.MeasuresWe measured walking function, muscle strength, activities in daily living, motor and cognitive function.ResultsWe recruited 150 patients (30% female) who fulfilled our inclusion and exclusion criteria. The primary outcome recovery of walking function was achieved after a median of 28.5 days (IQR=45) after rehabilitation onset and after a median of 81.5 days (IQR=64) after onset of illness. Our final multivariate model for recovery of walking function included two clinical variables from baseline: the Functional Status Score ICU (adjusted HR=1.07 (95% CI 1.03 to 1.12) and the ability to reach forward in cm (adjusted HR=1.02 (95% CI 1.00 to 1.04). All secondary outcomes but not pain improved significantly in the first 8 weeks after study onset.ConclusionsWe found good recovery of walking function for most patients and described the recovery of walking function of people with ICU-acquired muscle weakness.Trials Registrations NumberSächsische Landesärztekammer EK-BR-32/13-1; DRKS00007181, German Register of Clinical Trials.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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