• Internal medicine · Aug 2021

    Review Case Reports

    High-dose-infliximab-associated Cerebral Venous Sinus Thrombosis: A Case Report and Review of the Literature.

    • Juri Tatsuoka, Takahiro Igarashi, Ryuta Kajimoto, Masato Kobayashi, Nobuhiro Moro, Takeshi Suma, Hideki Oshima, and Atsuo Yoshino.
    • Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Japan.
    • Intern. Med. 2021 Aug 15; 60 (16): 2677-2681.

    AbstractA 28-year-old woman experienced severe headache and right homonymous hemianopia after receiving high-dose infliximab for Crohn's disease. Computed tomography showed hemorrhagic infarction in the left temporal and parietal lobes. An angiogram revealed left transverse to sigmoid sinus occlusion and a stagnated Labbe vein. The patient was treated surgically and achieved a good outcome. Inflammatory bowel diseases are known to accompany venous and arterial thrombosis in 1-2% of cases. Recently, infliximab has been suggested to increase this possibility. A case of Crohn's disease presenting with cerebral sinus thrombosis in the remission period during long-term/high-dose use of infliximab is presented. In addition, infliximab-associated thrombosis cases were reviewed.

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