• Internal medicine · Aug 2021

    Case Reports

    Ramucirumab-related Oral Pyogenic Granuloma: A Report of Two Cases.

    • Tadanobu Aragaki, Nobuyoshi Tomomatsu, Yasuyuki Michi, Hisashi Hosaka, Yasuyuki Fukai, Misa Iijima, and Tetsuya Yoda.
    • Section of Dentistry and Oral Surgery, Gunma Prefectural Cancer Center, Japan.
    • Intern. Med. 2021 Aug 15; 60 (16): 260126052601-2605.

    AbstractPyogenic granuloma (PG) is a granulomatous elevated lesion that occurs on the skin and mucous membranes. We herein report two cases of intra-oral PG that developed during the administration of ramucirumab for gastric cancer. Case 1 involved a 55-year-old man with a 6-mm tumor on the right tongue, and case 2 involved a 67-year-old man with a 5-mm tumor on the upper lip. The imbalance in angiogenesis caused by ramucirumab and the deterioration in the local oral environment were suggested to have caused the PG. Medical and dental collaboration is essential during the administration of ramucirumab.

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