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Behavioural pharmacology · Aug 2021
The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice.
- Anna U Odland, Jesper L Kristensen, and Jesper T Andreasen.
- Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
- Behav Pharmacol. 2021 Aug 1; 32 (5): 448-452.
AbstractPsychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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