• Jiaofeng Huang, Heng Lin, Yinlian Wu, Yingying Fang, Rahul Kumar, Gongping Chen, and Su Lin.
• Department of Liver Research Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
• Am. J. Transplant. 2020 Jul 1; 20 (7): 1879-1881.

AbstractCoronavirus Disease 2019 (COVID-19) has become a pandemic since March 2020. We describe here 2 cases of COVID-19 infection in a posttransplant setting. First one is a 59-year-old renal transplant recipient; the second is a 51-year-old allogeneic bone marrow transplant recipient. Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. After the diagnosis of COVID-19, immunosuppressive agents were discontinued and methylprednisolone with prophylactic antibiotics were initiated, however, the lung injury progressed. The T cells were extremely low in both patients after infection. Both patients died despite the maximal mechanical ventilatory support. Therefore, the prognosis of COVID-19 pneumonia following transplantation is not optimistic and remains guarded. Lower T cell count may be a surrogate for poor outcome.© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.

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