• Luca A Carbonaro, Giovanni Di Leo, Paola Clauser, Rubina M Trimboli, Nicola Verardi, Maria P Fedeli, Rossano Girometti, Alfredo Tafà, Paola Bruscoli, Gianni Saguatti, Massimo Bazzocchi, and Francesco Sardanelli.
• Radiology Unit, Research Hospital Policlinico San Donato, San Donato Milanese, Milan, Italy.
• Eur J Radiol. 2016 Apr 1; 85 (4): 808-14.

ObjectivesTo estimate the impact on recall rate (RR) of digital breast tomosynthesis (DBT) associated with digital mammography (DM+DBT), compared to DM alone, evaluate the impact of double reading (DR) and review the literature.MethodsEthics committees approved this multicenter study. Patients gave informed consent. Women recalled from population-based screening reading were included. Reference standard was histology and/or ≥ 1 year follow up. Negative multiple assessment was considered for patients lost at follow up. Two blinded readers (R1, R2) evaluated first DM and subsequently DM+DBT. RR, sensitivity, specificity, accuracy, positive and negative predictive values (PPV, NPV), were calculated for R1, R2, and DR. Cohen κ and χ(2) were used for R1-R2 agreement and RR related to breast density.ResultsWe included 280 cases (41 malignancies, 66 benign lesions, and 173 negative examinations). The RR reduction was 43% (R1), 58% (R2), 43% (DR). Sensitivity, specificity, accuracy, PPV and NPV were: 93%, 67%, 71%, 33%, 98% for R1; 88%, 73%, 75%, 36%, 97% for R2; 98%, 55%, 61%, 27%, 99% for DR. The agreement was higher for DM+DBT (κ=0.459 versus κ=0.234). Reduction in RR was independent from breast density (p=0.992).ConclusionDBT was confirmed to reduce RR, as shown by 13 of 15 previous studies (reported reduction 6-82%, median 31%). This reduction is confirmed when using DR. DBT allows an increased inter-reader agreement.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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