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Anesthesia and analgesia · Jul 1985
Vecuronium and d-tubocurarine combination: potentiation of effect.
- R K Mirakhur, F M Gibson, and C J Ferres.
- Anesth. Analg. 1985 Jul 1; 64 (7): 711-4.
AbstractTo evaluate possible potentiation of neuromuscular blocking effect of a combination of vecuronium and d-tubocurarine, cumulative dose-response curves were constructed to compare the potency of this combination with vecuronium and d-tubocurarine given alone. Ten patients each were given incremental injections of 80 micrograms/kg d-tubocurarine or 5 micrograms/kg vecuronium plus 40 micrograms/kg d-tubocurarine, the data for incremental administration of 10 micrograms/kg vecuronium being used from our previously published study (7). The results showed the combination of vecuronium plus d-tubocurarine to be significantly more potent (P less than 0.05) than would be expected from a simple additive effect of the individual drugs given alone. The ED95 doses of d-tubocurarine and vecuronium were 530 micrograms/kg and 57 micrograms/kg, respectively, when administered alone, but when administered together, the ED95 doses were 160 and 20 micrograms/kg, respectively.
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